Hydrochloric Acid → HCID 10121328, compound

Participants

Reaction Steps

A solution of ethyl 1-{4-[(4-{[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)-amino]phenyl}ethyl)amino]methyl}piperidin-1-yl)sulfonyl]-phenyl}-1H-pyrazole-4-carboxylate (0.118 g, 0.18 mmol) and 0.8 mL of 1N NaOH in 10 mL methanol was heated at reflux overnight. On cooling the reaction was neutralized with 0.8 mL of 1N HCl. The reaction mixture was concentrated in vacuo and triturated with H2O. The solids were filtered and dried (high vacuum) to give 0.095 g of the title compound as an off white solid.

Provenance & Evidence