Hydrochloric Acid → HCID 70001219, compound

Participants

Reaction Steps

A solution of 3-(3-{4-[(4-{[((2S)-2-hydroxy-2-{4-hydroxy-3-[(methyl-sulfonyl)-amino]-phenyl}ethyl)amino]methyl}-1-piperidinyl)sulfonyl]-phenyl}-1,2,4-oxadiazol-5-yl)propanoic acid methyl ester (0.150 g, 0.24 mmol) in 15 ml of methanol and 0.470 ml of 1N NaOH was heated at reflux for 14 hours. To the reaction mixture was added 0.470 ml of 1N HCl . The solvent was removed in vacuo and the resulting solid was triturated with water, then with ethyl acetate to give the final product (0.088 g) as a white solid.

Provenance & Evidence