HCID 69999782, compound → HCID 44331426, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (2S)-2-{[4-(4-{[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)-amino]-phenyl}-ethyl)amino]methyl}piperidin-1-yl)benzoyl]-amino}butanedioic acid dibenzyl ester (0.074 g, 0.1 mmol) and 0.08 g of 10% palladium on carbon in 4 mL ethanol-cyclohexene (3:1, v/v) was heated at 78° C. until the reduction was complete. The catalyst was filtered (Celite) and the cake was washed with hot methanol. The solvent was removed in vacuo to give 0.023 g of the title compound.

Provenance & Evidence