Ethylmorpholine → HCID 70000822, compound

Participants

Reaction Steps

A solution of 4-(4-(dimethoxymethyl)piperidinyl)benzoic acid (0.450 g, 1.6 mmol), 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide HCl (0.340 g, 1.77 mmol), N-ethyl morpholine (0.50 mL, 3.9 mmol), hydroxybenzotriazole (0.239 g, 1.77 mmol), and L-leucine ethyl ester HCl (0.322 g, 1.8 mmol) in THF (15 mL) was stirred at ambient temperature overnight. The solvent was evaporated in vacuo and the residue was dissolved in methylene chloride. The organic phase was washed with 1N HCl, 1N NaOH, brine and dried (Na2SO4). The solvent was evaporated in vacuo and the residue purified by flash chromatography (methylene chloride-methanol, 19:1) to give 0.163 g of the title compound.

Provenance & Evidence