Hexahydro-1,4-diazepine → HCID 18674986, compound

HRID 1634870Notes

Reaction equation

HRID 1634870 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=2[CH2:15][Cl:16])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[NH:21]1[CH2:27][CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[ClH:16].[ClH:16].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=2[CH2:15][N:21]2[CH2:27][CH2:26][CH2:25][N:24]([CH2:15][C:14]3[CH:17]=[CH:18][CH:19]=[CH:20][C:13]=3[C:5]3[CH:6]=[C:7]([O:11][CH3:12])[C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=3)[CH2:23][CH2:22]2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10]

Participants

3

Reactant 2

HCID 68163Hexahydro-1,4-diazepineHCID 120163292-(3,4,5-Trimethoxyphenyl)benzyl chloride

Product 1

HCID 18674986HCID 18674986, compound

Procedure

2-(3,4,5-Trimethoxyphenyl)benzyl chloride (307 mg) and homopiperazine (53 mg) were reacted in the same manner as in Example 1 to obtain a free base of the title compound. This compound was converted into a dihydrochloride in the same manner as in Example 1.

Sources & evidence

ORD record
ord-7dd1ecd7675d418593627cdbd19a581e
Source dataset
uspto-grants-2003_01
Patent number
US06509329B1

Reaction notes

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