Hexahydro-1,4-diazepine → HCID 18674968, compound

Participants

Reaction Steps

3-Chloromethyl-5-(3,4,5-trimethoxyphenyl)pyridine (70 mg) and homopiperazine (12 mg) were reacted in the same manner as in Example 1 to obtain the title compound as a free base. Yield: 56 mg (76%). 1H-NMR (400 MHz, CDCl3) δ: 1.85 (br, 2H), 2.73 (br, 4H), 2.79 (t, 4H, J=5.9 Hz), 3.73 (s, 4H), 3.90 (s, 6H), 3.94 (s, 12H), 6.76 (s, 4H), 7.82 (s, 2H), 8.53 (d, 2H, J=2.0 Hz), 8.68 (d, 2H, J=2.1 Hz). m/z (EI): 614 [M+].

Provenance & Evidence