Hexahydro-1,4-diazepine → HCID 18675004, compound

HRID 1634893Notes

Reaction equation

HRID 1634893 reaction equation
Cl[CH2:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:14]=[C:13]([O:15][CH3:16])[C:12]([O:17][CH3:18])=[C:11]([O:19][CH3:20])[CH:10]=2)=[N:7][CH:8]=1.[NH:21]1[CH2:27][CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[CH3:20][O:19][C:11]1[CH:10]=[C:9]([C:6]2[CH:5]=[CH:4][C:3]([CH2:2][N:21]3[CH2:27][CH2:26][CH2:25][N:24]([CH2:2][C:3]4[CH:4]=[CH:5][C:6]([C:9]5[CH:14]=[C:13]([O:15][CH3:16])[C:12]([O:17][CH3:18])=[C:11]([O:19][CH3:20])[CH:10]=5)=[N:7][CH:8]=4)[CH2:23][CH2:22]3)=[CH:8][N:7]=2)[CH:14]=[C:13]([O:15][CH3:16])[C:12]=1[O:17][CH3:18]

Participants

3

Reactant 2

HCID 68163Hexahydro-1,4-diazepineHCID 120434865-Chloromethyl-2-(3,4,5-trimethoxyphenyl)pyridine

Product 1

HCID 18675004HCID 18675004, compound

Procedure

5-Chloromethyl-2-(3,4,5-trimethoxyphenyl)pyridine (294 mg) and homopiperazine (50 mg) were reacted in the same manner as in Example 1 to obtain the title compound as a free base.

Sources & evidence

ORD record
ord-c22d4dced768439e81efc8521366f423
Source dataset
uspto-grants-2003_01
Patent number
US06509329B1

Reaction notes

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