Hexahydro-1,4-diazepine → HCID 23554340, compound

HRID 1634902Notes

Reaction equation

HRID 1634902 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([C:9]#[C:10][C:11]2[CH:16]=[C:15]([O:17][CH3:18])[C:14]([O:19][CH3:20])=[C:13]([O:21][CH3:22])[CH:12]=2)[CH:4]=1.[NH:23]1[CH2:29][CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>>[CH3:22][O:21][C:13]1[CH:12]=[C:11]([C:10]#[C:9][C:5]2[CH:4]=[C:3]([CH2:2][N:23]3[CH2:29][CH2:28][CH2:27][N:26]([CH2:2][C:3]4[CH:8]=[CH:7][N:6]=[C:5]([C:9]#[C:10][C:11]5[CH:16]=[C:15]([O:17][CH3:18])[C:14]([O:19][CH3:20])=[C:13]([O:21][CH3:22])[CH:12]=5)[CH:4]=4)[CH2:25][CH2:24]3)[CH:8]=[CH:7][N:6]=2)[CH:16]=[C:15]([O:17][CH3:18])[C:14]=1[O:19][CH3:20]

Participants

3

Reactant 2

HCID 68163Hexahydro-1,4-diazepineHCID 18674979HCID 18674979, compound

Product 1

HCID 23554340HCID 23554340, compound

Procedure

4-Chloromethyl-2-(3,4,5-Trimethoxyphenylethynyl)-pyridine (230 mg) and homopiperazine (32 mg) were reacted in the same manner in Example 1 to obtain the title compound as a free base.

Sources & evidence

ORD record
ord-c5c6c8ed9aee47ffa187870d48ccff96
Source dataset
uspto-grants-2003_01
Patent number
US06509329B1

Reaction notes

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