Sodium borohydride → HCID 18546814, compound

HRID 1634905Notes

Reaction equation

HRID 1634905 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[N:18]=[CH:17][N:16]=[C:15]([CH:19]=[O:20])[CH:14]=2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[BH4-].[Na+]>CO>[OH:20][CH2:19][C:15]1[CH:14]=[C:13]([C:5]2[CH:4]=[C:3]([O:2][CH3:1])[C:8]([O:9][CH3:10])=[C:7]([O:11][CH3:12])[CH:6]=2)[N:18]=[CH:17][N:16]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 18546789HCID 18546789, compound

Product 1

HCID 18546814HCID 18546814, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

6-(3,4,5-Trimethoxyphenyl)pyrimidine-4-carboaldehyde (364 mg) was dissolved in methanol (50 mL), and to the solution sodium borohydride (25 mg) was added under ice cooling, and the mixture was stirred at room temperature for 2 hours. The reaction mixture was concentrated under reduced pressure, and the residue was purified by column chromatography on silica gel (chloroform:methanol=50:1) to obtain the title compound.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe residue was purified by column chromatography on silica gel (chloroform:methanol=50:1)

Sources & evidence

ORD record
ord-f4be5c892ef44fc3ae09c14ac3da99fd
Source dataset
uspto-grants-2003_01
Patent number
US06509329B1

Reaction notes

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