3,4,5-Trimethoxybenzeneboronic acid → 4-methyl-2-(3,4,5-Trimethoxyphenyl)-pyrimidine

HRID 1634908Notes

Reaction equation

HRID 1634908 reaction equation
Br[C:2]1[N:7]=[C:6]([CH3:8])[CH:5]=[CH:4][N:3]=1.[CH3:9][O:10][C:11]1[CH:12]=[C:13](B(O)O)[CH:14]=[C:15]([O:19][CH3:20])[C:16]=1[O:17][CH3:18]>>[CH3:8][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([C:13]2[CH:14]=[C:15]([O:19][CH3:20])[C:16]([O:17][CH3:18])=[C:11]([O:10][CH3:9])[CH:12]=2)[N:7]=1

Participants

3

Reactant 2

HCID 27343903,4,5-Trimethoxybenzeneboronic acidHCID 109429282-Bromo-4-methylpyrimidine

Product 1

HCID 186749984-methyl-2-(3,4,5-Trimethoxyphenyl)-pyrimidine

Procedure

2-Bromo−4-methylpyrimidine (1.5 g) and 3,4,5-trimethoxyphenylboronic acid (1.83 g) were reacted in the same manner as in Preparation Example 1 to obtain the title compound.

Sources & evidence

ORD record
ord-bad1b7ca9e894fdc84670fc13f7666e1
Source dataset
uspto-grants-2003_01
Patent number
US06509329B1

Reaction notes

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