Hexahydro-1,4-diazepine → HCID 18675005, compound

HRID 1634910Notes

Reaction equation

HRID 1634910 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([C:9]2[CH:14]=[C:13]([O:15][CH3:16])[C:12]([O:17][CH3:18])=[C:11]([O:19][CH3:20])[CH:10]=2)[N:4]=1.[NH:21]1[CH2:27][CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[CH3:20][O:19][C:11]1[CH:10]=[C:9]([C:5]2[N:4]=[C:3]([CH2:2][N:21]3[CH2:27][CH2:26][CH2:25][N:24]([CH2:2][C:3]4[CH:8]=[CH:7][N:6]=[C:5]([C:9]5[CH:10]=[C:11]([O:19][CH3:20])[C:12]([O:17][CH3:18])=[C:13]([O:15][CH3:16])[CH:14]=5)[N:4]=4)[CH2:23][CH2:22]3)[CH:8]=[CH:7][N:6]=2)[CH:14]=[C:13]([O:15][CH3:16])[C:12]=1[O:17][CH3:18]

Participants

3

Reactant 2

HCID 68163Hexahydro-1,4-diazepineHCID 18674982HCID 18674982, compound

Product 1

HCID 18675005HCID 18675005, compound

Procedure

4-Chloromethyl-2-(3,4,5-trimethoxyphenyl)pyrimidine (300 mg) and homopiperazine (51 mg) were reacted in the same manner as in Example 1 to obtain the title compound as a free base.

Sources & evidence

ORD record
ord-6eabaa65f1f74a589fcece72578bb46a
Source dataset
uspto-grants-2003_01
Patent number
US06509329B1

Reaction notes

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