HCID 18674970, compound → HCID 18674997, compound

Participants

Reaction Conditions

Reaction Steps

5-Hydroxymethyl-2-methylthio-4-(3,4,5-trimethoxyphen yl)pyrimidine (1.75 g) was dissolved in a mixed solvent of ethanol (50 mL) and aqueous ammonia (5 mL). Raney nickel (R=100, wet type, 17.0 g) was added to the solution, and the mixture was stirred at 90° C. for 2.5 hours. The reaction mixture was filtered through celite, and the filtrate was concentrated under reduced pressure. Water was added to the residue to conduct extraction with ethyl acetate. The resultant organic layer was washed with saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (hexane:ethyl acetate=9:1) to obtain the title compound.

Provenance & Evidence