HRID1634999

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7172308

4-Bromo-2-fluorobenzyl cyanide

C8H5BrFN

HCID10987806

(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)boronic acid

C10H12BNO4

PRODUCTS

生成物

结构：CC1(C)OC(=O)Nc2ccc(-c3ccc(CC#N)c(F)c3)cc21

HCID23509618

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

Prepared according to procedure B from 4-bromo-2-fluorophenylacetonitrile (T. Alessi A. H. P. U.S. Pat. No.: 4,895,862) and (1,4-dihydro-4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acid. A grey solid; mp 253-256° C. 1HNMR(DMSO-d6) −δ10.35 (s,1H) 7.67-7.49 (m,5H), 6.97 (d,1H;J=8.6 Hz) 4.09 (s,2H) 1.67 (s, 6H); MS [M−H]− m/z 309. Anal. Calc. For C18H15N2FO2. 0.15 H2O: C,69.07, H, 4.93, N, 8.95. Found C,69.27, H 5.05, N, 8.50

WORKUP

后处理

customPrepared