HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-fluoroanisole → 6-(3-Fluoro-4-methoxy-phenyl)4,4-dimethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-fluoroanisole | HCID 75378 | — |
| Reactant | (4,4-Dimethyl-2-oxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)boronic acid | HCID 10987806 | — |
| Product | 6-(3-Fluoro-4-methoxy-phenyl)4,4-dimethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one | HCID 23509640 | — |
Reaction Steps
Prepared according to procedure B from 4-bromo-2-fluoroanisole and (1,4-dihydro-4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acid. White solid: mp 210-211° C. 1H-NMR (DMSO-d6), δ10.27(s,1H), 7.52-7.60 (m,3H), 7.45 (d,1H, J=8.6 Hz), 7.22 (t, 1H; J=8.9 Hz), 6.94 (d,1H, J=8.8 Hz), 3.87 (s,3H), 1.66 (s, 6H). MS [M−H]−m/z=300. Anal. Calc. For C17H16FNO3: C, 67.76, H, 5.35, N, 4.65. Found: C,67.88, H,5.39, N, 4.70.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06509334B1 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-7b1054c3fe7547feab86b4b93fc8d195 |
| Source note | uspto-grants-2003_01 |