HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-bromopyridine → 6-(6-Amino-pyridin-3-yl)-4,4-dimethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-bromopyridine | HCID 70622 | — |
| Reactant | (4,4-Dimethyl-2-oxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)boronic acid | HCID 10987806 | — |
| Product | 6-(6-Amino-pyridin-3-yl)-4,4-dimethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one | HCID 12094504 | — |
Reaction Steps
Prepared according to procedure B from 2-amino-5-bromopyridine and (1,4-dihydro-4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acid. White crystals, mp 257-259° C. 1H-NMR (DMSO-d6) δ10.20 (s, 1H), 8.22 (d,1H, J=2.38 Hz) 7.69,7.66 (dd, 1H, J=2.5, 2.5 Hz), 7.42 (m,2H), 6.89 (d,1H, J=8.8 Hz), 6.49 (d, 1H, J=8.64 Hz), 6.02 (s,2H), 1.64 (s,6H); MS m/z 269 M+. Anal. Calcd. For C15H15N3O2.17H2O: C, 66.15, H, 5.68, N, 15.43. Found C, 66.10, H, 5.81, N, 15.02.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06509334B1 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-829fcf1a3a29483bb7493f59d1a953d7 |
| Source note | uspto-grants-2003_01 |