Methanesulfonyl chloride → HCID 9936686, compound

HRID 1635029Notes

Reaction equation

CS([N:5]1[C:13]2[C:8](=[CH:9][C:10]([C:14]([C:22]3[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=3)([OH:21])[C:15]3[N:19]([CH3:20])[CH:18]=[N:17][CH:16]=3)=[CH:11][CH:12]=2)[CH:7]=[C:6]1C1C=CC=C(Cl)C=1)(=O)=O.[CH3:36][S:37](Cl)(=[O:39])=[O:38]>>[CH3:36][S:37]([N:5]1[C:13]2[C:8](=[CH:9][C:10]([C:14]([C:22]3[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=3)([OH:21])[C:15]3[N:19]([CH3:20])[CH:18]=[N:17][CH:16]=3)=[CH:11][CH:12]=2)[C:7]([C:23]2[CH:22]=[CH:27][CH:26]=[C:25]([Cl:28])[CH:24]=2)=[CH:6]1)(=[O:39])=[O:38]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 18469124HCID 18469124, compound

Product 1

HCID 9936686HCID 9936686, compound

Procedure

Alternatively, the compound of Example 2, (±)-1-methylsulfonyl-(3-chlorophenyl)-5-[(4-chlorophenyl) hydroxyl (1-methyl-1H-imidazol-5-yl) methyl] indole was also made analogously to the method described for making Example Y, using methanesulfonyl chloride in place of 4-morpholinecarbonyl chloride. Yield: 77%. MS (Calc.): 526.46, MS(ES): 526.

Sources & evidence

ORD record: ord-e8e46f7a1cce42c48e3a3b94d71599c8
Source dataset: uspto-grants-2003_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06509336B1

Reaction notes

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