Triethylamine → HCID 11348025, compound

Participants

Reaction Steps

To a solution of 3-amino-2-[carboxymethyl-(4-methoxybenzenesulfonyl)-amino]propionic acid methyl ester trifluoraoetic acid salt (2.11 grams, 6.1 mmol) in methylene chloride (5 ml) is added 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (1.76 grams, 9.2 mmol) and triethyamine (3.4 ml, 24.4 mmol). The resulting mixture is stirred overnight, diluted wit ethyl acetate and washed with 1N hydrochlori acid. The organic layer is dried (sodium sulfate), filtered and concentrated. The crude product is purified by silica gel chromatography (elution with ethyl acetate) to provide 1-(4-methoxybenzenesufonyl)-5-oxo-piperazine-2-carboxylic acid methyl ester.

Provenance & Evidence