N,N-di-n-Butyl-2-benzyloxyacetamide → N,N-di-n-Butyl-2-hydroxyacetamide

HRID 1635077Notes

Reaction equation

HRID 1635077 reaction equation
[CH2:1]([N:5]([CH2:17][CH2:18][CH2:19][CH3:20])[C:6](=[O:16])[CH2:7][O:8]CC1C=CC=CC=1)[CH2:2][CH2:3][CH3:4]>C(O)C.[Pd].[C]>[CH2:1]([N:5]([CH2:17][CH2:18][CH2:19][CH3:20])[C:6](=[O:16])[CH2:7][OH:8])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 1

HCID 18675619N,N-di-n-Butyl-2-benzyloxyacetamide

Product 1

HCID 11008655N,N-di-n-Butyl-2-hydroxyacetamideYield 111.1%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

4 g of N,N-di-n-butyl-2-benzyloxyacetamide were dissolved in 50 ml of ethanol, and a spatula tip of Pd/carbon was added. The mixture was stirred under a hydrogen atmosphere for 16 hours, and then the catalyst was filtered off and the solvent was distilled off. 3 g of an oil were isolated and were immediately reacted further.

Workup

  1. filtrationthe catalyst was filtered off
  2. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-a9fb9dcbd46a4b5199a190bd6340d452
Source dataset
uspto-grants-2003_01
Patent number
US06509341B1

Reaction notes

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