Benzoyl Peroxide → HCID 18675872, compound

HRID 1635088Notes

Reaction equation

HRID 1635088 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH3:8])[C:3]=1[O:9][CH3:10].[Br:11]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH2:8][Br:11])[C:3]=1[O:9][CH3:10]

Participants

5

Reactant 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 105830464-Chloro-3-methoxy-2-methylpyridine

Product 1

HCID 18675872HCID 18675872, compound

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Procedure

4-Chloro-3-methoxy-2-methyl-pyridine (6.12 g) is dissolved in carbon tetrachloride (80 ml) then N-bromo-succinimide (7.12 g) and benzoyl peroxide (1 g) are added. The reaction mixture is refluxed under UV irradiation for 1.5 hour. The solid is filtered after cooling and the solvent evaporated. The desired product is purified by chromatography on silica gel.

Workup

  1. temperatureThe reaction mixture is refluxed under UV irradiation for 1.5 hour
  2. filtrationThe solid is filtered
  3. temperatureafter cooling
  4. customthe solvent evaporated
  5. customThe desired product is purified by chromatography on silica gel

Sources & evidence

ORD record
ord-6591c0c517204113a4c93daf9a5f06cb
Source dataset
uspto-grants-2003_01
Patent number
US06509349B1

Reaction notes

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