HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1635095Generated: October 27, 2026
Acetonitrile → 8-(3-Aminopiperidinyl)-1-Ethyl-9-Methoxy-4-Oxo-4H-Quinolizine-3-Carboxylic Acid, Ethyl Ester
https://huagongshe.com/reaction/1635095
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Ethyl-8-chloro-1-ethyl-9-methoxy-4-oxo-4H-quinolizine-3-carboxylate | HCID 11185968 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 8-(3-Aminopiperidinyl)-1-Ethyl-9-Methoxy-4-Oxo-4H-Quinolizine-3-Carboxylic Acid, Ethyl Ester | HCID 86589542 | — |
Reaction Steps
Ethyl-8-chloro-1-ethyl-9-methoxy-4-oxo-4H-quinolizine-3-carboxylate (Precursor A) (0.05 g) is dissolved in acetonitrile (3 ml) and triethylamine (0.3 ml). To this solution is added 3-S-aminopiperidine dihydrochloride (Precursor E) (0.055 g) and the mixture is stirred at 40° C. for five days. The reaction mixture is evaporated and the desired product obtained by recrystallization in isopropyl alcohol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06509349B1 |
|---|
| Source dataset | uspto-grants-2003_01 |
|---|
| ORD ID | ord-8d075cad5dc74ba19434fcb20591b3fc |
|---|
| Source note | uspto-grants-2003_01 |
|---|
