tert-Butyl bromoacetate → HCID 12052436, compound

HRID 1635125Notes

Reaction equation

HRID 1635125 reaction equation
[CH2:1]([C:5]1[O:6][C:7]2[CH:24]=[CH:23][CH:22]=[CH:21][C:8]=2[C:9]=1[C:10]([C:12]1[CH:17]=[C:16]([Br:18])[C:15]([OH:19])=[C:14]([Br:20])[CH:13]=1)=[O:11])[CH2:2][CH2:3][CH3:4].Br[CH2:26][C:27]([O:29]C(C)(C)C)=[O:28]>>[Br:18][C:16]1[CH:17]=[C:12]([C:10]([C:9]2[C:8]3[CH:21]=[CH:22][CH:23]=[CH:24][C:7]=3[O:6][C:5]=2[CH2:1][CH2:2][CH2:3][CH3:4])=[O:11])[CH:13]=[C:14]([Br:20])[C:15]=1[O:19][CH2:26][C:27]([OH:29])=[O:28]

Participants

3

Reactant 2

HCID 79177tert-Butyl bromoacetateHCID 9846653HCID 9846653, compound

Product 1

HCID 12052436HCID 12052436, compound

Procedure

This compound was prepared from (2-butyl-benzofuran-3-yl)-(3,5-dibromo-4-hydroxy-phenyl)-methanone and tert-butyl bromoacetate in substantially the same manner, as described in Example 2, and was obtained as an off-white solid, mp 92-94° C.; MS m/e 508 (M+); Analysis for: C21H18Br2O5 Calc'd: C, 49.44; H, 3.56 Found: C, 47.24; H, 3.59

Workup

  1. customwas obtained as an off-white solid, mp 92-94° C.

Sources & evidence

ORD record
ord-817cc6860c34477f9cde17e4c0f3d903
Source dataset
uspto-grants-2003_01
Patent number
US06509360B1

Reaction notes

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