(2'-Methyl-3-nitro-biphenyl-4-yl)-carbamic acid tert.-butyl ester → Carbamic acid,(3-amino-2'-methyl[1,1'-biphenyl]-4-yl)-,1,1-dimethylethyl ester

HRID 1635198Notes

Reaction equation

HRID 1635198 reaction equation
[C:1]([O:5][C:6](=[O:24])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[CH3:20])=[CH:10][C:9]=1[N+:21]([O-])=O)([CH3:4])([CH3:3])[CH3:2]>[Ni]>[C:1]([O:5][C:6](=[O:24])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[CH3:20])=[CH:10][C:9]=1[NH2:21])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 67290097(2'-Methyl-3-nitro-biphenyl-4-yl)-carbamic acid tert.-butyl ester

Product 1

HCID 67288955Carbamic acid,(3-amino-2'-methyl[1,1'-biphenyl]-4-yl)-,1,1-dimethylethyl ester

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

Prepared from (2′-methyl-3-nitro-biphenyl-4-yl)-carbamic acid tert.-butyl ester (Example C9) by catalytic hydrogenation with Raney-Ni according to the general procedure G (method a). Obtained as a white powder (281 mg).

Sources & evidence

ORD record
ord-ed15e0cb144c43ce8c12972e69dafd1a
Source dataset
uspto-grants-2003_01
Patent number
US06509328B1

Reaction notes

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