(3'-Fluoro-3-nitro-biphenyl-4-yl)-carbamic acid tert.-butyl ester → (3-Amino-3'-fluoro-biphenyl-4-yl)-carbamic acid tert.-butyl ester

HRID 1635211Notes

Reaction equation

HRID 1635211 reaction equation
[C:1]([O:5][C:6](=[O:24])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[CH:15]=2)=[CH:10][C:9]=1[N+:21]([O-])=O)([CH3:4])([CH3:3])[CH3:2]>[Pd]>[C:1]([O:5][C:6](=[O:24])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[CH:15]=2)=[CH:10][C:9]=1[NH2:21])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 69592831(3'-Fluoro-3-nitro-biphenyl-4-yl)-carbamic acid tert.-butyl ester

Product 1

HCID 69592797(3-Amino-3'-fluoro-biphenyl-4-yl)-carbamic acid tert.-butyl ester

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Prepared from (3′-fluoro-3-nitro-biphenyl-4-yl)-carbamic acid tert.-butyl ester (Example B11) by catalytic hydrogenation with Pd/C according to the general procedure G (method a). Obtained as a brown solid (3.40 g).

Sources & evidence

ORD record
ord-df892fc606254656a31fb78c78cd02f9
Source dataset
uspto-grants-2003_01
Patent number
US06509328B1

Reaction notes

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