HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium ethyl malonate → 3-Oxo-3-(3-[1,2,4]triazol-4-yl-phenyl)-propionic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium ethyl malonate | HCID 3446434 | — |
| Reactant | Magnesium Chloride | HCID 5360315 | — |
| Reactant | 3-(4H-1,2,4-triazol-4-yl)benzoic acid | HCID 6484684 | — |
| Reactant | ethyl chloroformate Et3N | HCID 19692316 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 3-Oxo-3-(3-[1,2,4]triazol-4-yl-phenyl)-propionic acid ethyl ester | HCID 69592875 | — |
Reaction Steps
Prepared from 3-[1,2,4]triazol-4-yl-benzoic acid [prepared by reaction of 3-aminobenzoic acid with hydrazine hydrate and triethyl orthoformate in acetic acid at 120° C.] by activation with ethyl chloroformate/Et3N and reaction with ethyl malonate potassium salt with Et3N and MgCl2 in CH3CN according to general procedure H (method a). Obtained as a white solid (5.74 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06509328B1 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-5c28a52ca0ad409f940bedc9d477946b |
| Source note | uspto-grants-2003_01 |