Ethyl 2-cyanopyridine-4-carboxylate → 3-(2-Cyano-pyridin-4-yl)-3-oxo-propionic acid tert-butyl ester

HRID 1635229Notes

Reaction equation

HRID 1635229 reaction equation
C(O[C:4](=[O:13])[C:5]1[CH:10]=[CH:9][N:8]=[C:7]([C:11]#[N:12])[CH:6]=1)C.[C:14]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])(=[O:16])[CH3:15].[Li]>>[C:18]([O:17][C:14](=[O:16])[CH2:15][C:4]([C:5]1[CH:10]=[CH:9][N:8]=[C:7]([C:11]#[N:12])[CH:6]=1)=[O:13])([CH3:21])([CH3:20])[CH3:19]

Participants

3

Reactant 2

HCID 13415157Ethyl 2-cyanopyridine-4-carboxylateHCID 86586795Lithium Tert-butyl Acetate

Product 1

HCID 695928163-(2-Cyano-pyridin-4-yl)-3-oxo-propionic acid tert-butyl ester

Procedure

Prepared from 2-cyano-isonicotinic acid ethyl ester [CAS-No. 58481-14-4] by treatment with lithium tert.-butyl acetate according to general procedure H (method b). Obtained as a light brown solid (7.70 g).

Sources & evidence

ORD record
ord-83699436881c4bada1739d2074f5b40f
Source dataset
uspto-grants-2003_01
Patent number
US06509328B1

Reaction notes

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