HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-(2-methylsulfanyl-imidazol-1-yl)-benzoate → 3-[3-(2-Methylsulfanyl-imidazol-1-yl)-phenyl]-3-oxo-propionic acid tert.-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-(2-methylsulfanyl-imidazol-1-yl)-benzoate | HCID 22224839 | — |
| Reactant | Lithium Tert-butyl Acetate | HCID 86586795 | — |
| Product | 3-[3-(2-Methylsulfanyl-imidazol-1-yl)-phenyl]-3-oxo-propionic acid tert.-butyl ester | HCID 69592760 | — |
Reaction Steps
Prepared from ethyl 3-(2-methylsulfanyl-imidazol-1-yl)-benzoate [prepared by esterification of 3-(2-methoxymethylsulfanyl-imidazol-1-yl)-benzoic acid [CAS-No. 108035-46-7] with conc. H2SO4 in EtOH, followed by treatment methyl iodide and NaH in THF/DMF] by treatment with lithium tert.-butyl acetate according to general procedure H (method b). Obtained as a light brown oil (4.41 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06509328B1 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-665ffb1afbd04e2b8294f8eac9c7345c |
| Source note | uspto-grants-2003_01 |