HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → HCID 69592852, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Potassium ethyl malonate | HCID 3446434 | — |
| Reactant | Magnesium Chloride | HCID 5360315 | — |
| Reactant | HCID 21942520 | HCID 21942520 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 69592852 | HCID 69592852 | — |
Reaction Steps
Prepared from 5-cyano-2-fluoro-benzoyl chloride [prepared from the corresponding acid [CAS-No. 146328-87-2] by treatment with SOCl2, cat. DMF in toluene at 80° C.] by reaction with ethyl malonate potassium salt with Et3N and MgCl2 in CH3CN according to general procedure H (method a). Obtained as a light yellow solid (3.85 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06509328B1 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-43e8821b41d04df886535280ed98f768 |
| Source note | uspto-grants-2003_01 |