HRID1635290

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC1(C)OC(=O)C=C(c2cccc(-n3cncn3)c2)O1

HCID22224837

未命名化合物

结构：CC(C)(C)OC(=O)Nc1ccc(C#Cc2ccc(F)cc2)cc1N

HCID69486641

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)Nc1ccc(C#Cc2ccc(F)cc2)cc1NC(=O)CC(=O)c1cccc(-n2cncn2)c1

HCID86588023

未命名化合物

PROCEDURE

实验过程

Prepared from [2-amino-4-(4-fluoro-phenylethynyl)-phenyl]-carbamic acid tert.-butyl ester (Example G33) and 2,2-dimethyl-6-(3-[1,2,4]triazol-1-yl-phenyl)-[1,3]dioxin-4-one (Example J13) according to the general procedure K. Obtained as a yellow solid (230 mg).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-20ea9d9e799d4e70b6043c191886214d
来源数据集: uspto-grants-2003_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06509328B1
来源说明: uspto-grants-2003_01

反应 SMILES

[C:1]([O:5][C:6](=[O:24])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]#[C:15][C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)=[CH:10][C:9]=1[NH2:23])([CH3:4])([CH3:3])[CH3:2].CC1(C)[O:31][C:30](=O)[CH:29]=[C:28]([C:33]2[CH:38]=[CH:37][CH:36]=[C:35]([N:39]3[CH:43]=[N:42][CH:41]=[N:40]3)[CH:34]=2)[O:27]1>>[C:1]([O:5][C:6](=[O:24])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]#[C:15][C:16]2[CH:17]=[CH:18][C:19]([F:22])=[CH:20][CH:21]=2)=[CH:10][C:9]=1[NH:23][C:30](=[O:31])[CH2:29][C:28](=[O:27])[C:33]1[CH:38]=[CH:37][CH:36]=[C:35]([N:39]2[CH:43]=[N:42][CH:41]=[N:40]2)[CH:34]=1)([CH3:4])([CH3:2])[CH3:3]