6-(3-Imidazol-1-yl-phenyl)-2,2-dimethyl-[1,3]dioxin-4-one → HCID 86588036, compound

HRID 1635302Notes

Reaction equation

HRID 1635302 reaction equation
[C:1]([O:5][C:6](=[O:26])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=2[O:21][CH2:22][O:23][CH3:24])=[CH:10][C:9]=1[NH2:25])([CH3:4])([CH3:3])[CH3:2].[N:27]1([C:32]2[CH:33]=[C:34]([C:38]3[O:43]C(C)(C)[O:41][C:40](=O)[CH:39]=3)[CH:35]=[CH:36][CH:37]=2)[CH:31]=[CH:30][N:29]=[CH:28]1>>[C:1]([O:5][C:6](=[O:26])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=2[O:21][CH2:22][O:23][CH3:24])=[CH:10][C:9]=1[NH:25][C:40](=[O:41])[CH2:39][C:38]([C:34]1[CH:35]=[CH:36][CH:37]=[C:32]([N:27]2[CH:31]=[CH:30][N:29]=[CH:28]2)[CH:33]=1)=[O:43])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 222248956-(3-Imidazol-1-yl-phenyl)-2,2-dimethyl-[1,3]dioxin-4-oneHCID 69592814HCID 69592814, compound

Product 1

HCID 86588036HCID 86588036, compound

Procedure

Prepared from (3-amino-4′-fluoro-2′-methoxymethoxy-biphenyl-4-yl)-carbamic acid tert.-butyl ester (Example G42) (181 mg, 0.5 mmol) and 6-(3-imidazol-1-yl-phenyl)-2,2-dimethyl-[1,3]dioxin-4-one (Example J10) (135 mg, 0.5 mmol) according to the general procedure K. Obtained as a yellow amorphous substance (221 mg).

Workup

  1. customObtained as a yellow amorphous substance (221 mg)

Sources & evidence

ORD record
ord-b282eb6a727d46e2a09657840e09ad9c
Source dataset
uspto-grants-2003_01
Patent number
US06509328B1

Reaction notes

Loading…