HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl (3-amino-4'-fluoro-[1,1'-biphenyl]-4-YL)carbamate → {4'-Fluoro-3-[3-oxo-3-(3-tetrazol-1-yl-phenyl)-propionylamino]-biphenyl-4-yl}-carbamic acid tert.-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl (3-amino-4'-fluoro-[1,1'-biphenyl]-4-YL)carbamate | HCID 59737201 | — |
| Reactant | 3-Oxo-3-(3-tetrazol-1-yl-phenyl)-propionic acid ethyl ester | HCID 69592791 | — |
| Product | {4'-Fluoro-3-[3-oxo-3-(3-tetrazol-1-yl-phenyl)-propionylamino]-biphenyl-4-yl}-carbamic acid tert.-butyl ester | HCID 86588041 | — |
Reaction Steps
Prepared from (3-amino-4′-fluoro-biphenyl-4-yl)-carbamic acid tert.-butyl ester (Example G39) and 3-oxo-3-(3-tetrazol-1-yl-phenyl)-propionic acid ethyl ester (Example H15) according to the general procedure K. Obtained as a light yellow solid (159 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06509328B1 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-ed251346d1b142ceba9f28821d3ac3e1 |
| Source note | uspto-grants-2003_01 |