HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl (3-amino-2'-fluoro-[1,1'-biphenyl]-4-yl)carbamate → {3-[3-(2-Cyano-pyridin-4-yl)-3-oxo-propionylamino]-2'-fluoro-biphenyl-4-yl}-carbamic acid tert.-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl (3-amino-2'-fluoro-[1,1'-biphenyl]-4-yl)carbamate | HCID 67361423 | — |
| Reactant | 3-(2-Cyano-pyridin-4-yl)-3-oxo-propionic acid tert-butyl ester | HCID 69592816 | — |
| Product | {3-[3-(2-Cyano-pyridin-4-yl)-3-oxo-propionylamino]-2'-fluoro-biphenyl-4-yl}-carbamic acid tert.-butyl ester | HCID 86588049 | — |
Reaction Steps
Prepared from (3-amino-2′-fluoro-biphenyl-4-yl)-carbamic acid tert.-butyl ester (Example G37) and 3-(2-cyano-pyridin-4-yl)-3-oxo-propionic acid tert.-butyl ester (Example H10) according to the general procedure K. Obtained as a white solid (151 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06509328B1 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-37b95c4f12574da68a9cb4879c550874 |
| Source note | uspto-grants-2003_01 |