HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (E)-4-(3-chlorophenyl)-8-(2-phenylethynyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (2-Amino-4-phenylethynyl-phenyl)-carbamic acid tert-butyl ester | HCID 11404065 | — |
| Reactant | 6-(3-Chloro-phenyl)-2,2-dimethyl-[1,3]dioxin-4-one | HCID 22224690 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (E)-4-(3-chlorophenyl)-8-(2-phenylethynyl)-1H-benzo[b][1,4]diazepin-2(3H)-one | HCID 9864190 | — |
Reaction Steps
Prepared from (2-amino-4-phenylethynyl-phenyl)-carbamic acid tert.-butyl ester (Example G2) and 6-(3-chloro-phenyl)-2,2-dimethyl-[1,3]dioxin-4-one (Example J6) according to the general procedure K. The obtained material was deprotected and cyclized by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as an orange solid (155 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06509328B1 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-41ec6dac33ec4ae0b57643f688d140d6 |
| Source note | uspto-grants-2003_01 |