HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 8-Benzoyl-4-thiophen-2-yl-1,3-dihydro-benzo[b][1,4]diazepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 86588008 | HCID 86588008 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 8-Benzoyl-4-thiophen-2-yl-1,3-dihydro-benzo[b][1,4]diazepin-2-one | HCID 22224700 | 19.2% |
Reaction Steps
Prepared from [4-benzoyl-2-(3-oxo-3-thiophen-2-yl-propionylamino)-phenyl]-carbamic acid tert.-butyl ester (Example K19) (54 mg, 0.12 mmol) by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as a yellow solid (8 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06509328B1 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-32ff6b27c2ff41b8a7b8056490e4d065 |
| Source note | uspto-grants-2003_01 |