HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 8-(4-Fluoro-phenyl)-4-(3-nitro-phenyl)-1,3-dihydro-benzo[b][1,4]diazepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 86588028 | HCID 86588028 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 8-(4-Fluoro-phenyl)-4-(3-nitro-phenyl)-1,3-dihydro-benzo[b][1,4]diazepin-2-one | HCID 22224819 | — |
Reaction Steps
Prepared from {4′-fluoro-3-[3-(3-nitro-phenyl)-3-oxo-propionylamino]-biphenyl-4-yl}-carbamic acid tert.-butyl ester (Example K42) by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as a light yellow solid (719 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06509328B1 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-63f8ef9e6894425998aa5352d6a9a9d5 |
| Source note | uspto-grants-2003_01 |