HCID 22224688, compound → HCID 22224871, compound

HRID 1635404Notes

Reaction equation

HRID 1635404 reaction equation
C([O:8][C:9]1[N:14]=[CH:13][C:12]([C:15]2[CH:16]=[CH:17][C:18]3[N:24]=[C:23]([C:25]4[CH:30]=[CH:29][CH:28]=[C:27]([N:31]5[CH:35]=[CH:34][N:33]=[CH:32]5)[CH:26]=4)[CH2:22][C:21](=[O:36])[NH:20][C:19]=3[CH:37]=2)=[CH:11][CH:10]=1)C1C=CC=CC=1>[Ni]>[N:31]1([C:27]2[CH:26]=[C:25]([C:23]3[CH2:22][C:21](=[O:36])[NH:20][C:19]4[CH:37]=[C:15]([C:12]5[CH:11]=[CH:10][C:9](=[O:8])[NH:14][CH:13]=5)[CH:16]=[CH:17][C:18]=4[N:24]=3)[CH:30]=[CH:29][CH:28]=2)[CH:35]=[CH:34][N:33]=[CH:32]1

Participants

3

Reactant 1

HCID 22224688HCID 22224688, compound

Product 1

HCID 22224871HCID 22224871, compound

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

Prepared from 8-(6-benzyloxy-pyridin-3-yl)-4-(3-imidazol-1-yl-phenyl)-1,3-dihydro-benzo[b][1,4]diazepin-2-one (Example 74) by catalytic hydrogenation with Raney-Ni according to the general procedure G (method a). Obtained as a light yellow solid (17 mg).

Sources & evidence

ORD record
ord-02f9e95b62a04c78a31af12fd3158dcb
Source dataset
uspto-grants-2003_01
Patent number
US06509328B1

Reaction notes

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