HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 2-Chloroisonicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 4-Pyridinecarboxylic acid, 1-oxide | HCID 26130 | — |
| Product | 2-Chloroisonicotinic acid | HCID 236985 | 65.4% |
Reaction Steps
A mixture of isonicotinic acid N-oxide (28.0 g, 0.2 mol) and phosphorus oxychloride (120.0 g, 0.8 mol) was heated at reflux for 7 h. The reaction mixture was cooled and carefully poured into 600 mL of ice water. The precipitate was collected by filtration to give 20.6 g (65% yield) of product as a pale yellow solid, mp: 248-249 C (lit: 250-252 C).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06509361B1 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-2e5b0fb551f247d597ad11fd2fae6da2 |
| Source note | uspto-grants-2003_01 |