Hydroxide → HCID 66758316, compound

Participants

Reaction Steps

To a solution of 1-[3—(7-(2-acetoxyethyl)oxy-5,11-dihydro[1]benzoxepino[2,3-b]pyridin-5-ylidene)propyl]-4—(4-chlorophenyl)piperidin-4-ol (Example 50)(140 mg) in ethanol (5 ml) were added 15% sodiun hydroxide aqueous solution (2ml) and the mixture was heated to reflux for hour. Water and ethyl acetate were added to the reaction mixture, the organic layer was separated and washed with saturated aqueous sodium chloride, and dried with magnesium sulfate.

Provenance & Evidence