Acetic Acid → HCID 506049, compound

HRID 1635557Notes

Reaction equation

HRID 1635557 reaction equation
C[O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:15][CH2:14][CH2:13][C:12]2=[O:16])=[C:7]([NH:17][CH:18]([CH2:21][CH3:22])[CH2:19][CH3:20])[CH:6]=1)=[O:4].[OH-].[Na+].C(O)(=O)C>CO>[C:3]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:15][CH2:14][CH2:13][C:12]2=[O:16])=[C:7]([NH:17][CH:18]([CH2:21][CH3:22])[CH2:19][CH3:20])[CH:6]=1)([OH:4])=[O:2]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 14798Sodium HydroxideHCID 10662297HCID 10662297, compound

Product 1

HCID 506049HCID 506049, compoundYield 87.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of the above ester (0.150 g, 0.49 mmol) in 1 mL of methanol was treated with 1N sodium hydroxide (2 mL) and the resulting mixture was stirred at ambient temperature for 16 h. The reaction mixture was acidified with glacial acetic acid and a solid precipitated. The solid was collected by filtration, washed with water and dried to give 0.125 g (87%) of the title compound, mp 178-180° C.

Workup

  1. customa solid precipitated
  2. filtrationThe solid was collected by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-40486b5c6ba84a31b93838d4b747932b
Source dataset
uspto-grants-2003_01
Patent number
US06509359B1

Reaction notes

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