Thionyl Chloride → HCID 12011185, compound

Participants

Reaction Conditions

Reaction Steps

To 3 ml of thionyl chloride is added 2.39 g (9.5 mmol) of 1-(2′-chlorobenzyl)-4,5-dimethyl-2-hydroxymethyl-imidazole. The mixture is heated at 50° C. for about 5 min., and the thionyl chloride is evaporated in vacuo. The residue is dissolved in 10 ml of dichloromethane, then evaporated in vacuo. This is repeated twice to give 1-(2′-chlorobenzyl)-4,5-dimethyl-2-chloromethylimidazole as a cream colored foam which is used in next step without further purification.

Provenance & Evidence