HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrazole → (4-Pyrazol-1-yl-2-trifluoromethyl-phenyl)-(5H,11H-pyrrolo[2,1-c][1,4]benzodiazepin-10-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrazole | HCID 1048 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 9799697 | HCID 9799697 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (4-Pyrazol-1-yl-2-trifluoromethyl-phenyl)-(5H,11H-pyrrolo[2,1-c][1,4]benzodiazepin-10-yl)-methanone | HCID 9931997 | 54.9% |
Reaction Steps
In the manner of Example 2, employing (4-fluoro-2-trifluoromethyl-phenyl)-(5H, 11H-pyrrolo[2,1-c][1,4]benzodiazepin-10-yl)-methanone (1.0 g), 60% sodium hydride in oil (0.20 g), pyrazole (0.25 g) and dimethylformamide (35 ml). The product (0.62 g) was obtained as a colorless amorphous solid, MS, m/z: 423.2 (M+H)+, 445.2 (M+Na)+, 845.3 (2M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06511974B1 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-7a74a423b6e643ac8bfe90fb31d3c1e6 |
| Source note | uspto-grants-2003_01 |