HuagongsheHuagongshe Chemistry Print Report · For research reference only
Butyryl chloride → 1-{3-[4-(5H,11H-Pyrrolo[2,1-c][1,4]benzodiazepine-10-carbonyl)-phenyl]-pyrazol-1-yl}-butan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Butyryl chloride | HCID 8855 | — |
| Reactant | HCID 178519422 | HCID 178519422 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 1-{3-[4-(5H,11H-Pyrrolo[2,1-c][1,4]benzodiazepine-10-carbonyl)-phenyl]-pyrazol-1-yl}-butan-1-one | HCID 10310088 | 63.5% |
Reaction Steps
In the manner of Example 32, employing [4-(1H-pyrazol-3-yl)-phenyl]-(5H,11H-pyrrolo[2,1-c][1,4]benzodiazepin-10-yl)-methanone (0.71 g) in dry pyridine (10 ml) and butyryl chloride (0.32 g), the title compound (0.54 g) was obtained as a solid, m.p. 105-110° C.; MS, m/z: 424 (M)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06511974B1 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-f36d27303fd9465bb20cceab05c5e313 |
| Source note | uspto-grants-2003_01 |