HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Dichlorobenzoyl chloride → {4-[1-(2,4-Dichloro-benzoyl)-1H-pyrazol-3-yl]-phenyl}-(5H,11H-pyrrolo[2,1-c][1,4]benzodiazepin-10-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Dichlorobenzoyl chloride | HCID 66645 | — |
| Reactant | HCID 178519422 | HCID 178519422 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | {4-[1-(2,4-Dichloro-benzoyl)-1H-pyrazol-3-yl]-phenyl}-(5H,11H-pyrrolo[2,1-c][1,4]benzodiazepin-10-yl)-methanone | HCID 9936711 | 62.5% |
Reaction Steps
In the manner of Example 32, employing [4-(1H-pyrazol-3-yl)-phenyl]-(5H,11H-pyrrolo[2,1-c][1,4]benzodiazepin-10-yl)-methanone (0.71 g) in dry pyridine (20 ml) and 2,4-dichlorobenzoyl chloride (0.52 g), the title compound (0.66 g) was obtained as a crystalline solid, m.p. 180-182° C.; MS, m/z: 528 (M)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06511974B1 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-d27870bdf4a44dbabde3bd0b1cf022f9 |
| Source note | uspto-grants-2003_01 |