Methylhydrazine → HCID 3953327, compound

HRID 1635842Notes

Reaction equation

HRID 1635842 reaction equation
[CH:1]([C:3]([C:6]1[N:11]=[CH:10][C:9]([C:12]([OH:14])=[O:13])=[CH:8][CH:7]=1)=[CH:4]O)=O.[CH3:15][NH:16][NH2:17]>C(O)C>[CH3:15][N:16]1[CH:4]=[C:3]([C:6]2[N:11]=[CH:10][C:9]([C:12]([OH:14])=[O:13])=[CH:8][CH:7]=2)[CH:1]=[N:17]1

Participants

4

Reactant 2

HCID 6061MethylhydrazineHCID 3610278HCID 3610278, compound

Product 1

HCID 3953327HCID 3953327, compoundYield 64%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A suspension of 6-(1-formyl-2-hydroxyvinyl)pyridine-3-carboxylic acid (1.93 g) (Eastman Chemicals) in absolute ethanol (50 ml) and methylhydrazine (0.50 g) was stirred for 18 hours at room temperature. The reaction mixture was filtered to give the product (1.30 g). The filtrate was evaporated to give a solid which was recrystallized from ethyl acetate to give an analytical sample of the title compound (0.55 g), m.p. 262-264° C.

Workup

  1. filtrationThe reaction mixture was filtered

Sources & evidence

ORD record
ord-bc1a6fb647f5424a8a128c7b852e1d49
Source dataset
uspto-grants-2003_01
Patent number
US06511974B1

Reaction notes

Loading…