反应详情

To a stirred solution of 2-chloro-4-cyanobenzoic acid, methyl ester (24.3 g) in methanol (150 ml) was added 2.5N sodium hydroxide (54.5 ml). After stirring at room temperature. for 45 minutes, the solvent was removed in vacuo. The residue was dissolved in water, cooled in an ice bath, and made acidic with 2N hydrochloric acid (14 ml). The resulting precipitate was filtered and dried in vacuo to yield the title compound as a solid (22.55 g) m.p. 154-158° C.

1. customthe solvent was removed in vacuo
2. dissolutionThe residue was dissolved in water
3. temperaturecooled in an ice bath
4. filtrationThe resulting precipitate was filtered
5. customdried in vacuo