Sodium Hydroxide → HCID 22136183, compound

HRID 1635915Notes

Reaction equation

HRID 1635915 reaction equation
[C:1]1([C:7]2[N:11]3[CH:12]=[C:13]([C:20]([O:22]C)=[O:21])[C:14]4[C:19]([C:10]3=[CH:9][N:8]=2)=[CH:18][CH:17]=[CH:16][CH:15]=4)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>CO.O>[C:1]1([C:7]2[N:11]3[CH:12]=[C:13]([C:20]([OH:22])=[O:21])[C:14]4[C:19]([C:10]3=[CH:9][N:8]=2)=[CH:18][CH:17]=[CH:16][CH:15]=4)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 22136173HCID 22136173, compound

Product 1

HCID 22136183HCID 22136183, compoundYield 96.7%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A slurry of the product from part 8 (488 mg) and NaOH (226 mg) in 15 ml of methanol and 10 ml of water is stirred at 60° C. until a solution forms. The methanol is then evaporated in vacuo, and the remaining mixture is diluted with water. After adjusting the pH to 5-6 with 1N HCl, the solid is collected by filtration, washed with water and dried to give the title compound (450 mg) as a yellow solid, m.p. 187-90° C.

Workup

  1. customThe methanol is then evaporated in vacuo
  2. additionthe remaining mixture is diluted with water
  3. filtrationthe solid is collected by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-aeda90209c3e4f29b8934c374ebc3023
Source dataset
uspto-grants-2003_01
Patent number
US06511987B1

Reaction notes

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