反应详情

1.89 g of 2-chloro-6-fluoro-phenylacetic acid was suspended in 20 ml of concentrated nitric acid. After the addition of 10 ml of concentrated sulfuric acid, the resulting mixture was heated under reflux for 3.5 hours. After the reaction mixture was poured into ice water, the resulting precipitate was collected by filtration, washed with a small amount of purified water, and then dried. Thus, 1.83 g (78% yield) of the title compound was obtained as a white powder.

1. temperaturethe resulting mixture was heated
2. temperatureunder reflux for 3.5 hours
3. filtrationthe resulting precipitate was collected by filtration
4. washwashed with a small amount of purified water
5. customdried