Cyclohexene → HCID 69692245, compound

HRID 1635927Notes

Reaction equation

HRID 1635927 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:12][N:11]=[C:10]([NH:13][C:14](=[O:25])[CH:15]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[N+:16]([O-])=O)[C:9]=2[C:26]2[CH:31]=[CH:30][N:29]=[CH:28][CH:27]=2)=[CH:4][CH:3]=1.C1CCCCC=1>CO.[C].[Pd]>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:12][N:11]=[C:10]([NH:13][C:14](=[O:25])[CH:15]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[NH2:16])[C:9]=2[C:26]2[CH:27]=[CH:28][N:29]=[CH:30][CH:31]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 8079CyclohexeneHCID 86758813HCID 86758813, compound

Product 1

HCID 69692245HCID 69692245, compoundYield 79%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

11 mg of 5-(4-fluorophenyl)-3-(2-nitrophenylacetylamino)-4-(4-pyridyl)pyrazole was dissolved in 5 ml of methanol. Then, 100 mg of cyclohexene and 20 mg of 5% palladium-carbon were added thereto, followed by heating under reflux for 1 hour. After the reaction mixture was filtered, the filtrate was concentrated under reduced pressure to obtain 8 mg (79% yield) of the title compound as a light-brown powder.

Workup

  1. temperatureby heating
  2. temperatureunder reflux for 1 hour
  3. filtrationAfter the reaction mixture was filtered
  4. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-0fdf06c4b1a2485f8d90935ee2ce0258
Source dataset
uspto-grants-2003_01
Patent number
US06511997B1

Reaction notes

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