反应详情

A mixture of the ester of Example 23(d) (5.217 g, 20.0 mmol) and (PPh3)3RhCl (1.56 g, 1.69 mmol, Aldrich) in ethanol (60 mL) was stirred under a balloon of H2 for 23 h. The mixture was then filtered through celite and evaporated. The residue was purified by flash chromatography (5% ethyl acetate/hexanes→10%) to give 3-(2-Bromo-thiophen-3-yl)-propionic acid ethyl ester (4.507 g, 17.1 mmol, 85%).

1. filtrationThe mixture was then filtered through celite
2. customevaporated
3. customThe residue was purified by flash chromatography (5% ethyl acetate/hexanes→10%)