4-(Trifluoromethyl)benzoic acid → HCID 18673933, compound

HRID 1635981Notes

Reaction equation

HRID 1635981 reaction equation
FC(F)(F)C1C=CC(C(O)=O)=CC=1.[NH2:14][C:15]1[CH:16]=[CH:17][C:18]([O:21][C:22]2[CH:30]=[C:29]3[C:25]([CH2:26][CH2:27][C:28]3=[O:31])=[CH:24][CH:23]=2)=[N:19][CH:20]=1>>[NH2:14][C:15]1[CH:16]=[CH:17][C:18]([O:21][C:22]2[CH:23]=[CH:24][CH:25]=[C:29]3[C:30]=2[CH2:26][CH2:27][C:28]3=[O:31])=[N:19][CH:20]=1

Participants

3

Reactant 2

HCID 99664-(Trifluoromethyl)benzoic acidHCID 18673877HCID 18673877, compound

Product 1

HCID 18673933HCID 18673933, compound

Procedure

According to the same manner as that described in Example 1 except for using an equimolar amount of 4-(trifluoromethyl)benzoic acid in place of 3,4-dichlorobenzoic acid and using an equimolar amount of 6-[(5-amino-2-pyridinyl)oxy]-1-indanone obtained in Reference Example 18 in place of 4-[(5-amino-2-pyridinyl)oxy]-1-indanone, the reaction was carried out to obtain the titled compound.

Sources & evidence

ORD record
ord-8e86caed83b34a61872cbf4f490acbb4
Source dataset
uspto-grants-2003_01
Patent number
US06511995B1

Reaction notes

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