3,4-Difluorobenzoic acid → HCID 18673933, compound

HRID 1635982Notes

Reaction equation

HRID 1635982 reaction equation
FC1C=C(C=CC=1F)C(O)=[O:6].[CH2:12]1[C:20]2[C:15](=[CH:16][C:17]([O:21][C:22]3[N:27]=[CH:26][C:25]([NH2:28])=[CH:24][CH:23]=3)=[CH:18][CH:19]=2)[CH2:14][CH2:13]1>>[NH2:28][C:25]1[CH:24]=[CH:23][C:22]([O:21][C:17]2[CH:16]=[CH:15][CH:14]=[C:13]3[C:18]=2[CH2:19][CH2:20][C:12]3=[O:6])=[N:27][CH:26]=1

Participants

3

Reactant 2

HCID 991663,4-Difluorobenzoic acidHCID 18673921HCID 18673921, compound

Product 1

HCID 18673933HCID 18673933, compound

Procedure

According to the same manner as that described in Example 1 except for using an equimolar amount of 3,4-difluorobenzoic acid in place of 3,4-dichlorobenzoic acid and using an equimolar amount of 6-[(2,3-dihydro-1H-inden-5-yl)oxy]-3-pyridinylamine obtained in Reference Example 19 in place of 4-[(5-amino-2-pyridinyl)oxy]-1-indanone, the reaction was carried out to obtain the titled compound.

Sources & evidence

ORD record
ord-eb04bd817c994aa58d1771429137b5a1
Source dataset
uspto-grants-2003_01
Patent number
US06511995B1

Reaction notes

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